Clinical signs and diagnosis of osteogenesis imperfecta in three dogs.

摘要

Three young dogs with multiple fractures and without a history of substantial trauma were examined at Cornell University's veterinary teaching hospital. Radiographic findings included multiple fractures in various stages of healing and generalized osteopenia. Cultured fibroblasts from skin biopsy specimens were used to diagnose osteogenesis imperfecta. Structural abnormalities were found in type-I collagen from each dog.