Iodination of β-keto-sulfones using molecular iodine and hydrogen peroxide in aqueous medium: facile synthesis of -iodomethyl sulfones

摘要

The reaction of β-keto-sulfones with molecular iodine in the presence of aqueous acidic hydrogen peroxide yielded α-iodo β-keto-sulfones, which on treatment with aqueous alkali at room temperature underwent base-induced cleavage to afford corresponding α-iodomethyl sulfones in excellent yields.