Desloratadine is a new, nonsedating H-1 receptor antagonist, which has been shown to have good tolerability and to be effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and chronic idiopathic urticaria. The pharmacological profile of desloratadine exhibits particular advantages compared with other antihistamines in terms of binding and occupancy of the human H-1 receptor and its pharmacokinetics. This review describes aspects of these pharmacological properties, focusing on H-1 receptor antagonism by desloratadine, its predictable pharmacokinetics when administered with food and common medications, and its lack of effect on important drug transport molecules, such as P-glycoprotein and organic anion transport polypeptide.
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