Reduced beta-cell reserve and pancreatic volume in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation

Wei Christina; Thyagiarajan Manigandan; Hunt Linda; Cox Rachel; Bradley Karin; Elson Ruth; Hamilton-Shield Julian; Stevens Michael; Crowne Elizabeth

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Reduced beta-cell reserve and pancreatic volume in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation

机译：骨髓移植和全身照射治疗的儿童急性淋巴细胞白血病的幸存者中β细胞储备和胰腺体积减少

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BackgroundImpaired glucose tolerance (IGT) and diabetes mellitus (DM) occur more frequently after bone marrow transplantation and total body irradiation (BMT/TBI), but the mechanism is unclear. This study investigates insulin sensitivity, -cell reserve and pancreatic volume in adult survivors of childhood acute lymphoblastic leukaemia (ALL).

机译：背景受损的葡萄糖耐量（IGT）和糖尿病（DM）在骨髓移植和全身照射（BMT / TBI）后更频繁地发生，但机制尚不清楚。这项研究调查了儿童急性淋巴细胞白血病（ALL）的成年幸存者的胰岛素敏感性，-细胞储备和胰腺体积。

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《Clinical Endocrinology》 |2015年第1期|共9页
作者
Wei Christina; Thyagiarajan Manigandan; Hunt Linda; Cox Rachel; Bradley Karin; Elson Ruth; Hamilton-Shield Julian; Stevens Michael; Crowne Elizabeth;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Reduced beta-cell reserve and pancreatic volume in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation [J] . Wei Christina, Thyagiarajan Manigandan, Hunt Linda, Clinical Endocrinology . 2015,第1期

机译：骨髓移植和全身照射治疗的儿童急性淋巴细胞白血病的幸存者中β细胞储备和胰腺体积减少
2. Bone Mineral Density Corrected for Size in Childhood Leukaemia Survivors Treated with Haematopoietic Stem Cell Transplantation and Total Body Irradiation [J] . Wei Christina, Candler Toby, Davis Nikki, Hormone research in p?diatrics . 2018,第4期

机译：骨矿物质密度校正儿童白血病幸存者大小，用血液生物干细胞移植治疗及全身照射
3. Survivors of childhood leukaemia treated with haematopoietic stem cell transplantation and total body irradiation should undergo screening for diabetes by oral glucose tolerance tests [J] . Wei C., Unsworth R., Davis N., Diabetic medicine: A journal of the British Diabetic Association . 2016,第10期

机译：经造血干细胞移植和全身照射治疗的儿童白血病幸存者应通过口服葡萄糖耐量试验筛查是否患有糖尿病
4. Evidence for heterogeneous genetic associations with acute lymphoblastic leukemia (ALL) by cytogenetics, age, and sex in high-risk patients treated with matched unrelated donor allogeneic blood or marrow transplant (URD-BMT) [D] . Clay, Alyssa I. 2016

机译：通过匹配的无关供体同种异体造血或骨髓移植（URD-BMT）治疗的高危患者中，通过细胞遗传学，年龄和性别进行的与急性淋巴细胞白血病（ALL）异质遗传关联的证据
5. Auxological changes in UK survivors of childhood acute lymphoblastic leukaemia treated without cranial irradiation [O] . R A L Breene, R M Williams, J Hartle, 2011

机译：未经颅脑照射治疗的儿童急性淋巴细胞白血病的英国幸存者的助词变化
6. Allogeneic bone marrow transplantation in children with acute lymphoblastic leukaemia in the first and second complete remission conditioned with fractionated total body irradiation and cyclophosphamide or etoposide [O] . Wachowiak Jacek, Malicki Julian, Buczkowski Dariusz, 2002

机译：全身淋巴分次照射和环磷酰胺或依托泊苷对急性淋巴细胞性白血病患儿的第一和第二完全缓解进行同种异体骨髓移植

Reduced beta-cell reserve and pancreatic volume in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation

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