Plasma Is the Physiologic Buffer of Tissue Plasminogen Activator-Mediated Fibrinolysis: Rationale for Plasma-First Resuscitation after Life-Threatening Hemorrhage

摘要

BACKGROUND: Prehospital resuscitation with crystalloid exacerbates fibrinolysis, which is associated with high mortality. We hypothesized that plasma compared with crystalloid resuscitation prevents hyperfibrinolysis in a tissue plasminogen activator (tPA)-rich environment via preservation of proteins essential for regulation of fibrinolysis.