Taguchi approach-assisted optimization of spraying in non-solvent process for preparation of potassium perchlorate nanoparticles

摘要

In this study, Taguchi robust design as a statistical route was utilized to optimize the variables of spraying in non-solvent process in order to achieve KClO4 nanoparticles. The experimental factors of the spraying in non-solvent technique, which may be effective in KClO4 particle size, were optimized efficiently via Taguchi method. The procedure operating conditions, i.e., KClO4 concentration, solvent ratio, non-solvent identity, and spray steps, were considered at triple levels. The role of these operating conditions on the size of resulted KClO4 particles was evaluated quantitatively by analysis of variance (ANOVA). It was found that the particle size of KClO4 prepared by spraying in non-solvent technique might be adjusted efficiently by tuning the main parameters at the corresponding optimum level. Moreover, the optimal conditions for the preparing of KClO4 nanoparticles via the studied method were proposed. The ANOVA exhibited that 3 % (w/v) as KClO4 concentration, CHCl3 as type of non-solvent, solvent to non-solvent ratio of 1:6, and single-step spraying are optimal conditions for the production of KClO4 nanoparticles by spraying in non-solvent. Experimental data revealed that at optimum conditions of the process, the average particle size of produced KClO4 is about 41 nm. Meantime, KClO4 nanoparticles were prepared by supercritical carbon dioxide anti-solvent process for comparison. It was found that the size of the produced KClO4 particles is about 55 nm.