Evaluation of F-18-labeled icotinib derivatives as potential PET agents for tumor imaging

摘要

In this study, three F-18-labeled crown ether fused anilinoquinazoline derivatives ([F-18]11a-c) were synthesized and evaluated as potential tumor imaging probes. The biodistribution results of [F-18]11b were good. Compared with [F-18]-fludeoxyglucose and l-[F-18]-fluoroethyltyrosine in the same animal model, [F-18]11b had better tumor/brain, tumor/muscle, and tumor/blood uptake ratios. Overall, these results suggest that [F-18]11b is promising as a tumor imaging agent for positron emission tomography.