Age-associated alteration in naive and memory Th17 cell response in humans.

摘要

Th17 cells produce IL-17 that plays an important role in host defense. However, little is known about whether aging affects human Th17 cells. Here we demonstrated that healthy elderly people (age >/= 65) had a decreased frequency of IL-17-producing cells in memory CD4(+) T cells compared to healthy young people (age