Determination of the lipophilicity of some carbonyl derivatives of 2-aminoimidazolines-2 by reversed-phase thin-layer chromatography. part 2. the lipophilicity of 1, 6-diaryl-5, 7-(1H) dioxo-2, 3-dihydroimidazo [1,2-a] [1,3,5]triazines and 1-aryl-5,6

摘要

The lipophilicity of twenty five new carbonyl derivatives of 1-aryl-2-aminoimidazolines-2 (twenty 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo [1,2-a][1,3,5] triazines and five 1-aryl-5,6(1H)dioxo-2,3-dihydroimidazo [1,2-a] imidazoles) has been determined by RPTLC on commercial RP-18 silica gel plates with methanol-acetic acid-water as mobile phase. R_M values for all the compounds were linearly dependent on mobile phase methanol concentration within the range 60 to 90%. Experimental lipophilicity was determined by use of the calibration curve obtained for six standards and partition coefficients (as logP) of all the compounds were calculated by means of two different software packages - ChemPlus (Hyper-Chem) and SciLogP (Alchemy 2000). The values calculated with the SciLogP package correlated very well (r > 0.95) with the logP_(TLC) values; correlation was good (r > 0.8) for values calculated by use of the ChemPlus package. This suggests that both methodologies are suitable for calculation of the lipophilicity of dioxo derivatives of 2-aminoimidazoline.