Anticancer and Toxic Effects of Curry Leaf (Murraya koenigii) Extracts

摘要

Curry leaves (Murraya koenigii), native to South Asian countries are commonly used as a food flavoring agent and known to have antioxidant, anti-inflammatory and antidiabetic activities. The objectives of this study were to investigate the anticancer and toxic effects of Curry Leaf Extracts (CLE) in Caco-2 and HepG2 cells and to assess the phytochemical content and antioxidant activities of CLE. The Caco-2 human colon adenocarcinoma (ATCC HTB-37) cells and Hep2G human liver cells (ATCC HB-8065) and were obtained from the American Type Culture Collection (ATCC, Manassas, VA). For assay, 5x 104cells/well were seeded in a 24 well culture plate and incubated at 37°C and 5% CO2 until development of a monolayer. Cells were incubated with aqueous CLE at selected concentrations (0.2-0.8 jug mL~-1) for 12 and 24 h.