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Effect of mutating amino acids considered critical for hERG channel blocker activity on the profile of a hERG channel activator

机译：被认为对hERG通道阻滞剂活性至关重要的突变氨基酸对hERG通道激活剂谱的影响

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来源
《Journal of Pharmacological and Toxicological Methods》 |2014年第3期|共6页
作者
Mannikko Roope; Bridgland-Taylor Matthew; Pollard Chris;
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正文语种 eng
中图分类药理学;
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1. Effect of mutating amino acids considered critical for hERG channel blocker activity on the profile of a hERG channel activator [J] . Mannikko Roope, Bridgland-Taylor Matthew, Pollard Chris Journal of Pharmacological and Toxicological Methods . 2014,第3期

机译：被认为对hERG通道阻滞剂活性至关重要的突变氨基酸对hERG通道激活剂谱的影响
2. Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels [J] . TwinerM.J., DoucetteG.J., RaskyA., Chemical research in toxicology . 2012,第9期

机译：海洋藻毒素氮杂螺菌酸是hERG钾通道的开放状态阻滞剂
3. Proton block of the pore underlies the inhibition of hERG cardiac K~+ channels during acidosis [J] . Aaron C. Van Slyke, Yen May Cheng, Pouya Mafi, American Journal of Physiology . 2012,第6aPta1期

机译：毛孔的质子阻塞是酸中毒期间抑制hERG心脏K〜+通道的基础
4. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs [C] . Michael C. Sanguinetti, Jun Chen, David Fernandez, symposium on The hERG cardiac potassium channel: structure, function, and long QT syndrome . 2005

机译：结构各种药物对疱疹沟槽结合和电压依赖性块的物理化学基础
5. Characterization of the hERG potassium channels channel activation gate region. [D] . Wynia Smith, Sarah L. 2009

机译：hERG钾离子通道通道激活门区域的表征。
6. The marine algal toxin azaspiracid is an open state blocker of hERG potassium channels [O] . Michael J. Twiner, Gregory J. Doucette, Andrew Rasky, -1

机译：海藻藻毒素Azaspiracid是HERG钾通道的开放状态阻滞剂
7. Marine Algal Toxin Azaspiracid Is an Open-State Blocker of hERG Potassium Channels [O] . Michael C. Sanguinetti 2016

机译：海洋藻毒素azaspiracid是hERG钾通道的开放状态阻滞剂

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