A Randomized Open-Label Comparison of Lamotrigine and Valproate in Patients with Juvenile Myoclonic Epilepsy

摘要

The aim of this study was to evaluate the efficacy and tolerability of lamotrigine and valproate in patients with different types of generalized epilepsy characterized by myoclonic seizures as well as compare the efficacy of those two drugs. A pilot, randomized controlled trial analysis of 46 female patients (age 8-30 years) in alarge university hospital. All patients underwent several interictal EEG including routine awake and sleep EEGs. Lamotrigine was started at the dose of 500 mg day~-1and was progressively increased to a mean dose of 1500-2000 mg day~-4 in a time course of 8 weeks. The target maintenance dose for valproate was 800 mg day~-1 after starting valproate at the dose of 200 mg/12 h. The mean dose was reached within 4 weeks. Out of total 46 patients, 46 (100%) had juvenile myoclonic epilepsy; 43 (93.48%) had tonic-clonic; 5 (11%) had myoclonic absences. In the valproate and lamotrigine groups, there was significant reduction (p<0.001,p<0.001) in myoclonic seizure and tonic-clonic seizure frequencies.