Randomized Trial of Cefazolin Prophylaxis for Open Burch Retropubic Urethropexy

摘要

Objective: The objective of this study was to determine the efficacy of prophylactic cefazolin in preventing febrile and infectious morbidity after open Burch urethropexy.Methods: All women scheduled for a Burch without hysterectomy were screened for eligibility and 47 were randomly assigned to receive 2 g cefazolin intravenously preoperatively (n = 27) or no antibiotic (n = 20).Results: Febrile morbidity occurred in 6 of 47 (12.8%) overall. Infectious morbidity occurred in 8 of 47 (17%), 5 of 27 (18.6%) in the prophylaxis. group and in 3 of 20 (15%) of control subjects, which was not statistically significant. With 1 exception, all infections occurred after discharge and did not necessitate readmission. Urinary tract infection was the most common (7 of 47) and accounted for 89% of all infections.Conclusions: This data does not support the use of antibiotic prophylaxis for the Burch urethropexy. Because the rate of febrile and infectious morbidity is low, a case could be made for only treating patients with symptomatic infections.