Moisture sorption and permeability characteristics of polymer films: implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances.

Mwesigwa E; Basit AW; Buckton G

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Moisture sorption and permeability characteristics of polymer films: implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances.

机译：聚合物薄膜的水分吸收和渗透特性：用作含有可水解药物的固体剂型的阻隔涂层的意义。

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Moisture sorption and permeability characteristics of polymer films were studied and their effectiveness to protect a hydrolyzable drug assessed. Cast films were prepared from Eudragit L30 D-55, Eudragit EPO, Opadry AMB and Sepifilm LP dispersions, which were also applied onto tablet cores formulated with aspirin as a model moisture sensitive active ingredient. Sorption studies were undertaken using dynamic vapour sorption, ranging between 0% and 90% RH at 25 degrees C. Cast films exhibited fast equilibration (

机译：研究了聚合物薄膜的水分吸附和渗透特性，并评估了它们对保护可水解药物的有效性。由Eudragit L30 D-55，Eudragit EPO，Opadry AMB和Sepifilm LP分散体制备流延膜，然后将其涂在以阿司匹林为模型的水敏活性成分配制的片剂芯上。使用动态蒸气吸附进行吸附研究，动态蒸气吸附在25°C下相对湿度在0％到90％之间。流延薄膜表现出快速平衡（<或= 500 min，90％RH），产生III型等温线和非菲克动力学。 Sepifilm LP和Opadry AMB的溶解度系数最高，表明对水的偏爱更大。 Eudragit EPO是渗透性最低的薄膜，其次是Opadry AMB，Eudragit L30 D-55和Sepifilm LP（渗透系数为10（-6）-10（-7）cm（3）（STP）cm / cm（ 2）s cm Hg）。包衣芯净吸收水分减少，这与薄膜的渗透性特征相称。然而，在包衣芯中观察到更高的阿司匹林降解，其中Eudragit EPO成为最不有效的屏障。因此，膜的吸收/渗透特性与其作为保护性涂层的功能之间没有相关性。这些结果表明聚合物涂层不足以抵抗湿气并且不能防止与湿气有关的药物变质。

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《Journal of pharmaceutical sciences.》 |2008年第10期|共13页
作者
Mwesigwa E; Basit AW; Buckton G;
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正文语种 eng
中图分类药学;
关键词
Polymers; Eudragit; Moisture; Lateral posterior nucleus of thalamus; Erythropoietin; 聚合物; 红细胞生成素;

机译：Polymers;Eudragit;Moisture;Lateral posterior nucleus of thalamus;Erythropoietin;聚合物;红细胞生成素;

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1. Moisture sorption and permeability characteristics of polymer films: implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances. [J] . Mwesigwa E, Basit AW, Buckton G Journal of pharmaceutical sciences. . 2008,第10期

机译：聚合物薄膜的水分吸收和渗透特性：用作含有可水解药物的固体剂型的阻隔涂层的意义。
2. Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability [J] . Michael J. Cross, James E. Sidaway, Emma L. Wilkinson Biology Open . 2016,第10期

机译：心脏毒性药物赫赛汀和阿霉素抑制心脏微血管内皮细胞屏障形成，导致药物渗透性增强心脏毒性药物赫赛汀和阿霉素抑制心脏微血管内皮细胞屏障形成，导致药物通透性增加心脏毒性药物赫赛汀和阿霉素抑制心脏微血管内皮细胞屏障形成，导致药物增多渗透性
3. Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability [J] . Michael J. Cross, James E. Sidaway, Emma L. Wilkinson Biology Open . 2016,第10期

机译：心脏毒性药物赫赛汀和阿霉素抑制心脏微血管内皮细胞屏障形成，导致药物渗透性增强心脏毒性药物赫赛汀和阿霉素抑制心脏微血管内皮细胞屏障形成，导致药物通透性增加心脏毒性药物赫赛汀和阿霉素抑制心脏微血管内皮细胞屏障形成，导致药物增多渗透性
4. THE EFFECT OF POLYMERIC EXCIPIENT SELECTION AND PROCESS VARIABLES ON SOLID DRUG DOSAGE FORMS USING HOT MELT EXTRUSION [C] . Karen Coppens, Mark Hall, Pam Larsen, Society of Plastics Engineers Annual Technical Conference 2006(ANTEC 2006) vol.3; 20060507-11; Charlotte,NC(US) . 2006

机译：热熔挤出工艺对聚合物赋形剂选择和工艺变量对固体药物剂量的影响
5. Understanding curing of ethylcellulose film coating and in vitro in vivo performance of oral dosage forms with scientific regulatory implications on biowaiver. [D] . Lin, Zhongqiang. 2015

机译：了解乙基纤维素薄膜包衣的固化和口服剂型的体外体内性能，对生物豁免具有科学的监管意义。
6. The effect of pectin on swelling and permeability characteristics of free films containing Eudragit RL and/or RS as a coating formulation aimed for colonic drug delivery [O] . A. Akhgari, F. Farahmand, H. Afrasiabi Garekani, 2010

机译：果胶对包含Eudragit RL和/或RS作为用于结肠药物递送的包衣制剂的自由膜的溶胀和渗透特性的影响
7. Interaction between Polyethylene Films and Bromhexine HCl in Solid Dosage Forms. I. Effects of Moisture Contents in the Solid Dosage Forms on the Sorption of the Drug [O] . Takuya KUKITA, Akemi YAMAGUCHI, Akihiko OKAMOTO, 1989

机译：聚乙烯薄膜与溴己酮HCl以固体剂型相互作用。 I.水分含量在固体剂型中的影响对药物的吸附

Moisture sorption and permeability characteristics of polymer films: implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances.

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