Probiotics and functional gastrointestinal disorders.

摘要

According to the Rome III criteria, abdominal pain-related FGD in children may be categorized as functional dyspepsia, irritable bowel syndrome (IBS), abdominal migraine, and functional abdominal pain. At least 4 meta-analyses (3-6) and 1 systematic review (7) evaluated the effects of probiotics for the treatment of IBS, primarily in the adult population, and reached slightly different conclusions. Regarding the pediatric population, a Cochrane systematic review (8) (search date: December 2006) concluded that there is no evidence that lactobacillus supplementation is effective in the management of children with recurrent abdominal pain. Taking into account that the probiotic supplementation is not a homogeneous intervention, pooling data from different genera, species, strains, and doses of probiotics may result in misleading conclusions.