High-grade undifferentiated pleomorphic sarcoma of pelvis treated with curettage and bone graft after complete remission following caffeine-potentiated chemotherapy.

摘要

Undifferentiated pleomorphic sarcoma (formerly known as malignant fibrous histiocytoma: MFH) is a relatively rare primary malignant bone tumor first described by Norman and Feldman [1] as a malignant histiocytoma. It comprises approximately 6% of all bone tumors [2, 3]. It was reported that the osteosarcoma adjuvant or neoadjuvant chemo-therapeutic regimen is beneficial [4], and a good pathological response predicted better disease-free survival [5]. Caffeine is a xanthine analog that has a biochemical modulating effect as an inhibitor of DNA repair, and may inhibit the post-replication repair of sublethally damaged DNA [6, 7].