Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy.

摘要

Antiepileptic drug (AED)-related rash is well documented with older AEDs such as carbamazepine, phenobarbital, and phenytoin, and recent studies have implicated newer AEDs such as lamotrigine, oxcarbazepine (OXC), and zonisamide [1-4]. In patients with brain tumor-related epilepsy (BTRE) treated with old AEDs, the appearance of rash may be severe during radiotherapy (RT). The frequency is approximately 20% of cases where traditional AEDs such as carbamazepine, phenobarbital, and phenytoin are used [4]. The appearance of rash during RT among the new AEDs has not yet been described in the literature.