Multiple myeloma presenting as mandibular ill-defined radiolucent lesion with numb chin syndrome: a case report.

摘要

Multiple myeloma is a malignant neoplasm of plasma cells that is characterized by the production of pathologic M proteins, bone lesions, kidney disease, hyperviscosity, and hypercalcemia. Human leukocyte antigen studies suggest a genetic predisposition to the disease, which occurs equally in both genders, most often in patients aged older than 50 years. Anemia and skeletal pain are the most common presenting symptoms, and bone pain is caused by bone lysis that may result either directly from accumulation of tumor cells or indirectly from osteoclast-activating factors secreted by the malignant myeloma cells. Multiple myeloma manifestations of the head and neck are common but usually occur in the late stages of the disease; mandibular involvement with multiple myeloma as the initial presenting sign of the disease is extremely rare. In this case report we present a unique case of multiple myeloma with mandibular radiolucent lesion as the first sign of the disease.