METHOD OF DETERMINING RESPONSIVENESS OF PATIENT WITH MULTIPLE MYELOMA TO MEDICINE, AND MEDICINE FOR PREVENTION AND/OR TREATMENT OF BONE LESIONS IN PATIENT WITH MULTIPLE MYELOMA

摘要

To provide methods for determining whether a patient with multiple myeloma is responsive to a medicament containing a substance inhibiting the function of interleukin-34 (IL-34) as an active ingredient, and to provide medicines for the prevention and/or treatment of bone lesions in a patient with multiple myeloma.SOLUTION: The present invention relates to a method for determining responsiveness of a patient to a medicine for the prevention and/or treatment of bone lesions in a patient with multiple myeloma which contains a substance inhibiting the function of IL-34 as an active ingredient, the method comprising determining that the patient is responsive to the medicine when myeloma cells isolated from the patient are positive for IL-34 expression and negative for M-CSF expression. According to the present invention, by avoiding a therapeutic method using as a mechanism RANKL or M-CSF function inhibition which is easily accompanied by side effects, it is possible to provide a medicine using a mechanism of inhibiting the function of IL-34 considered to be a main factor of bone lesion, to a patient.SELECTED DRAWING: Figure 2