Concepts, challenges, and opportunities in allo-head and body reconstruction (AHBR)

摘要

Transplantation of human organs including the kidney, liver, heart, and lung has become a mainstay of clinical treatment. With allogeneic composite tissue transplantation (CTA), there are always the issues of practicality, immune rejection, and ethics, but joint efforts at the end of the last century at American University of Louisville and Kleinert Hand and Microsurgery Center team led to the design and completion of the first successful CTA preclinical model [1]. Based on this porcine model, five stages of postoperative tissue rejection were established, based on severity [2]. The immunosuppressive regimen implemented at this time included tacrolimus (FK-506), mycophenolate mofetil, and prednisone, . which successfully prevented CTA rejection [3]. This study formed the basis for hand allografts in the United States and the world [4], It has been 15 years since we completed the first successful human hand allograft; the patient recovered function well, without rejection of the transplanted hand, and continues to work and lead a normal social life [5].