Synthesis and X-ray structural studies of the dextro-rotatory enantiomer of methyl alpha-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl)-acetate isopropylsulfate

摘要

This study resolves conflicting data on a particular salt of the enantiomer of methyl alpha-5(4,5,6,7-tetrahydro(3,2-c)thieno pyridyl) (2-chlorophenyl) -acetate (S(+)clopidogrel). The title compound, (C16H17ClNO2S)(+) (C3H7O4S)(-), was obtained and successfully characterized by X-ray diffraction, NMR, TG/DSC/MS. This salt previously reported in the literature as a 2-propanol solvate of the hydrogen-sulfate salt appears to be actually an isopropylsulfate salt. (c) 2006 Elsevier B.V. All rights reserved.