Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

摘要

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with progressive and devastating memory impairment [1]. The majority of therapeutic strategies and drug development approaches for AD were based on dysfunction of acetylcholine to date, which mainly alleviate symptoms of AD [1]. A great amount of researches proposed that oxidative stress (OS) be an important and early factor in the pathogenesis of AD and contribute to beta-amyloid generation [2]. Nuclear factor E2-related factor 2 (Nrf2) is a novel transcription factor known to induce expression of a variety of cytoprotective and detoxification genes. Increasing evidence demonstrated that Nrf2/ARE pathway may be considered a therapeutic target for neurodegenerative diseases, including AD [3].