Detection of 5-fluorouracil surface contamination in near real time.

摘要

The 5-FU monitor is capable of detecting 10?ng/100?cm(2) (0.1?ng/cm(2)) using the electronic reader and 25?ng/100?cm(2) (0.25?ng/cm(2)) using the visual comparison method for the surfaces studied. The response of the monitors was compared to LC-MS/MS results for the same samples for validation and there was good correlation of the two methods but some differences in absolute response, especially at higher spiking levels for the surface samples.