Isolation, Structure Elucidation, and Biological Evaluation of 15-Amido-3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine, a New Alkaloid from Hyperbaena valida

摘要

A phytochemical investigation of the leaves of Hyperbaena valida resulted in the isolation and characterization of two erythrina-type alkaloids, 1 and 2, which were found to be antagonists at nicotinic receptors. Compound 1 was assigned as the new 15-amido-3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine and compound 2 as the known 3-demethoxy-2alpha,3alpha-methylenedioxyerythroculine. Antagonism of a 100 mu M nicotine response was observed for alkaloid 1 (IC_(50) value of 94 +- 8 mu M) and alkaloid 2 (IC_(50) value of 77 +- 19 mu M).