Pregnane-10,2-carbolactones from a Hawaiian Marine Sponge in the Genus Myrmekioderma

摘要

Four new pregnanes, 3 beta,4 beta-dihydroxy-17-methyl-17 alpha-pregna-5,13-diene-10,2-carbolactone (1), 6 beta-chloro-3 beta-hydroxy-17-methyl-17 alpha-pregna-4,13-diene-10,2-carbolactone (2), 3 beta-hydroxy-6 beta-methoxy-17-methyl-17 alpha-pregna-4,13-diene-10,2-carbolactone (3), and 3 beta,6 beta-dihydroxy-17-methyl-17 alpha-pregna-4,13-diene-10,2-carbolactone (4), were isolated from an undescribed species of Myrmekioderma Ehlers along with the known pregnane carbolactone (5). The structures of the new compounds were determined by spectroscopic methods and comparison with previously described compounds. Compound 5 showed almost 4-fold activation of pregnane X receptor, while 2 inhibited BACE1 with an IC50 value of 82 mu M.