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ANTITUMOUR COMPOUNDS FROM MARINE SPONGE OF THE GENUS DERCITUS
ANTITUMOUR COMPOUNDS FROM MARINE SPONGE OF THE GENUS DERCITUS
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机译:鹿角属海洋海绵中的反义化合物
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摘要
The invention relates to novel alkaloidcompounds of the formulae (I), (II) and (III): (I)(II) (III)wherein R1 is a group selected from -CH2CH2N(CH3)2,-CH2CH2N+(CH3)3X-, -CH2CH2N+(O-)(CH3)2, -CH=CH2,-CHO, and -COOR; X is halogen; R is hydrogen or loweralkyl; R2 is hydrogen or together with R3 is-N=CZ-S-; R3 together with R2 is -N=CZ-S- or is agroup selected from -NH2, -NHCOR, and hydrogen; Z isNO2, NH2 or hydrogen; R4 is hydrogen or loweralkyl, and R5 is a group selected from hydrogen,lower alkyl and lower alkanoyl. These compounds andpharmaceutical compositions containing therapeuticeffective amounts thereof are useful as antitumor andimmunomodulatory medications.
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