Intravenous immunoglobulin G improves neurobehavioral and histological outcomes after traumatic brain injury in mice

摘要

Intravenous immunoglobulin (IVIG) may improve neuroinflammation after traumatic brain injury (TBI). IVIG administration after TBI improved rotarod latencies over the first 7. days (p= 0.039) and water maze latencies over 29-32. days (p= 0.027), decreased F4/80-positive cells at 2 (p= 0.001) and 7. days (p < 0.001), decreased Fluoro-Jade B-positive cells (p= 0.020), increased NeuN-positive cells (p= 0.014), decreased IL-6 production at 4 (p= 0.032) and 24. h (p= 0.023), and decreased blood-brain barrier breakdown by IgG extravasation (p= 0.001) and brain edema (p= 0.006); however, TNF-α concentration was unchanged. IVIG administration was associated with long-term neurobehavioral and histological improvement through modulation of neuroinflammation and blood-brain barrier permeability in a murine TBI model.