Volumetric, acoustical and viscometric behavior of glycine and DL-alanine in aqueous furosemide solutions at different temperatures

摘要

Drug (furosemide)-amino acid (glycine and DL-alanine) interactions have been investigated in aqueous medium from density (rho), speed of sound (u) and viscosity (eta) studies. The density and speed of sound data has been employed to obtain partial molar volume(V-phi(0)), partial molar volume of transfer(Delta V-tr(phi)0), partial molar expansion coefficient(partial derivative V-phi(0) / partial derivative T)(p), second derivative(partial derivative V-2(phi)0 / partial derivative T-2)(p), isentropic compressibility(k(s)), partial molar isentropic compressibility (K-phi,s(0)) partial molar isentropic compressibility of transfer(Delta K-tr(phi,s)0). The viscosity data have been used to calculate the viscosity B-coefficients, its temperature derivative dB/dT, viscosity B-coefficient of transfer (Delta B-tr) and various thermodynamic parameters of activation of viscous flow for amino acids in furosemide solutions. A detailed insight into the physicochemical interactions e.g. ionic-hydrophilic, hydrophilic-hydrophilic and hydrophilic-hydrophobic interactions in the amino acid-drug system along with the structure-making/ structure-breaking tendency of amino acids have been retrieved through the perusal of these calculated parameters. (C) 2015 Elsevier B.V. All rights reserved.