Artificial epi-retinal prosthesis (AeRP)

摘要

There are several research projects going on around the world, which are attempting to develop a prosthetic device to restore sight to the blind. This paper describes the efforts of Second Sight of New York, Inc. The device being developed is called an Artificial epi-Retinal Prosthesis (AeRP), which is basically a small optical computer that fits into the intraocular space of the eye. The AeRP is designed to draw light into the device by specially designed fibre optics. The light is 'digitized' by the fibre optic system and then directed to individual photodiode cells making up concentric cylinders thus providing several hundred photodiode cells in the device. The produced electrical stimulation from each cell is then delivered to the retinal ganglion cells by a specially designed delivery system utilizing electrically conducting polymer strands (ECP), which sit on an 'umbrella' at the back of the device. The retinal ganglion cells receive the electrical stimulation, which would then be transmitted through the visual system of the brain. There are several innovations in this approach as compared to the other projects. They include, first the design, which will allow for a high number of PC to produce electrical stimulation that will stimulate multiple RGC per PC; the use of the ECP strands has not been used in such an approach before this. Tests have revealed that nerve cells have a good affinity for the material of the ECP. The use of the ECP as well as the fact that the AeRP is completely photovoltaic, with no external power sources, implies that there will not be high heat build-up in the back of the eye, which might damage RGC. A smaller version of the AeRP called the Mini epi-Retinal Prosthesis (MeRP) is the subject of a complimentary paper. It is being built now and will be tested in cell culture studies to determine the efficacy of the design and materials. No actual implants have been performed yet.