De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.

Lagu B; Tian D; Jeon Y; Li C; Wetzel JM; Nagarathnam D; Shen Q; Forray C; Chang RS; Broten TP; Ransom RW; Chan TB; OMalley SS; Schorn TW; Rodrigues AD; Kassahun K; Pettibone DJ; Freidinger RO; Gluchowski C

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De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.

机译：从头开始设计新型恶唑烷酮类似物，作为具有高口服生物利用度的有效且选择性的α1A肾上腺素能受体拮抗剂。

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《Journal of Medicinal Chemistry》 |2000年第15期|共4页
作者
Lagu B; Tian D; Jeon Y; Li C; Wetzel JM; Nagarathnam D; Shen Q; Forray C; Chang RS; Broten TP; Ransom RW; Chan TB; OMalley SS; Schorn TW; Rodrigues AD; Kassahun K; Pettibone DJ; Freidinger RO; Gluchowski C;
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正文语种 eng
中图分类药学;
关键词
Adrenergic alpha-Antagonists; Oxazoles; Receptors; Adrenergic; alpha-1; adrenergic receptor alpha(1a); 肾上腺素能α拮抗剂; 恶唑类; 受体; 肾上腺素能α1;

机译：Adrenergic alpha-Antagonists;Oxazoles;Receptors;Adrenergic;alpha-1;adrenergic receptor alpha(1a);肾上腺素能α拮抗剂;恶唑类;受体;肾上腺素能α1;

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1. De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. [J] . Lagu B, Tian D, Jeon Y, Journal of Medicinal Chemistry . 2000,第15期

机译：从头开始设计新型恶唑烷酮类似物，作为具有高口服生物利用度的有效且选择性的α1A肾上腺素能受体拮抗剂。
2. Discovery of a novel series of benzoic acid derivatives as potent and selective human beta(3) adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety [J] . Imanishi M, Nakajima Y, Tomishima Y, Journal of Medicinal Chemistry . 2008,第15期

机译：发现一种新型的苯甲酸衍生物作为具有良好口服生物利用度的有效和选择性人β（3）肾上腺素能受体激动剂。 3.含有联苯或联苯醚部分的苯乙醇氨基四氢萘（PEAT）骨架
3. Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta 3 adrenergic receptor agonists with good oral bioavailability. Part II [J] . Imanishi M, Itou S, Washizuka K, Journal of Medicinal Chemistry . 2008,第13期

机译：发现一系列新型的联苯苯甲酸衍生物，作为具有良好口服生物利用度的高效和选择性人β3肾上腺素能受体激动剂。第二部分
4. Modeling of alpha_1 Adrenergic Receptors: the Application in the Design of Selective alpha_(1B)-Adrenergic Antagonists [C] . Slavica Eric, Tomaz Solmajer, Marko Oblak American Peptide Symposium . 2006

机译：α11肾上腺素能受体的建模：选择性α_（1B）设计中的应用 - 肾上腺素能拮抗剂
5. Potent derivatives of the bradykinin B2 receptor antagonist Hoe 140 containing analogues of arginine and lysine with increased hydrophobicity. [D] . Kennedy, Kevin Joseph. 1999

机译：缓激肽B2受体拮抗剂Hoe 140的强效衍生物含有精氨酸和赖氨酸的类似物，疏水性增强。
6. Design and Microwave-Assisted Synthesis of Novel Macrocyclic Peptides Active at Melanocortin Receptors: Discovery of Potent and Selective hMC5R Receptor Antagonists [O] . Paolo Grieco, Minying Cai, Lu Liu, -1

机译：黑色素皮质激素受体活性的新型大环肽的设计和微波辅助合成：有效和选择性hMC5R受体拮抗剂的发现。
7. Quantitative structure–activity relationship study of new potent and selective antagonists at the 5-HT1Aand adrenergic α1dreceptors: Derivatives of spiroethyl phenyl(substituted)piperazine [O] . B. K. Sharma, P. Singh, Susheela Sharma 2006

机译：数量结构 - 活性关系研究5-HT1A和肾上腺素能α1drceptors的新有效和选择性拮抗剂：螺旋乙基苯基（取代）哌嗪的衍生物

De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.

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