Design and biocatalytic synthesis of pluronics-based nanomicellar self-assembly systems for drug encapsulation applications

摘要

Nano medicine is an emerging branch of pharmaceuticals, which is gaining considerable attention mainly due to its new and effective way of drug delivery. Various modes of drug delivery are still in their adolescent stage, polymer-based drug delivery system is one among these. In order to develop a novel and biocompatible nano-carrier for drug delivery through a "green" and, environmentally benign approach, herein, we report the design, synthesis and characterization of four novel pluronic-based amphiphilic copolymers. Candida antartica lipase was used to catalyze polymerization in the presence of molecular sieves under solventless conditions. The resulting copolymers were also investigated for their supramolecular organization and drug encapsulation capacity for biomedical applications.