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首页> 外文期刊>Journal of Macromolecular Science. Pure and Applied Chemistry >Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium
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Preparation of biocompatible system based on electrospun CMC/PVA nanofibers as controlled release carrier of diclofenac sodium

机译:基于电纺CMC / PVA纳米纤维作为双氯芬酸钠控释载体的生物相容性体系的制备

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摘要

Nanofibers of naturally modified polymer such as carboxymethyl cellulose (CMC) blended with poly(vinyl alcohol) (PVA) at different ratios was obtained by electrospinning technique. The blended solutions of CMC and PVA loaded with and without diclofenac sodium (DS) were electrospun using environmentally benign electrospinning technique in the absence of organic solvents. Scanning electron microscopy (SEM), Fourier transform infrared (FTIR), thermogravimetric analysis (TGA) were used to investigate the surface morphology functional groups, as well as the thermal stability of DS loaded CMC/PVA nanofibers mat. The mechanical properties of the as prepared electrospun nanofibers was also evaluated. The entrapment efficiency and the in vitro release of DS loaded CMC/PVA nanofibers were characterized using UV-Vis spectroscopy. The obtained results displayed that the blended nanofibers have shown a smooth morphology, no beads formation when the concentration of CMC was equal or below 5% and beads formation above 5%. FTIR data demonstrated that there were good interactions between CMC and PVA possibly via the formation of hydrogen bonds. The electrospun blended CMC/PVA nanofibers exhibit good mechanical properties. From the in vitro release data, it was found that with the presence of CMC, the release of DS from the nanofibers mats became sustained controlled. Due to the biocompatibility and low cost of the two blended polymers (CMC and PVA), the blended nanofibers system can be considered as one of the promising materials for the preparation of excellent drug carrier.
机译:通过静电纺丝技术获得了羧甲基纤维素(CMC)与聚乙烯醇(PVA)混合比例不同的天然改性聚合物的纳米纤维。在没有有机溶剂的情况下,使用环境良性电纺丝技术对装有和不含有双氯芬酸钠(DS)的CMC和PVA的混合溶液进行电纺丝。用扫描电子显微镜(SEM),傅立叶变换红外光谱(FTIR),热重分析(TGA)研究了表面形貌官能团以及DS负载的CMC / PVA纳米纤维垫的热稳定性。还评估了所制备的电纺纳米纤维的机械性能。使用UV-Vis光谱法表征了载有DS的CMC / PVA纳米纤维的包封效率和体外释放。获得的结果表明,当CMC的浓度等于或低于5%时,混合的纳米纤维显示出平滑的形态,没有珠子形成,并且高于5%时珠子形成。 FTIR数据表明,CMC和PVA之间可能存在氢键形成良好的相互作用。电纺CMC / PVA混合纳米纤维表现出良好的机械性能。从体外释放数据发现,在CMC存在下,DS从纳米纤维垫的释放变得持续受控。由于两种共混聚合物(CMC和PVA)的生物相容性和低成本,可以将共混纳米纤维系统视为制备优良药物载体的有前途的材料之一。

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