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首页> 外文期刊>Journal of Lipid Research >Role of sulfatide in normal and pathological cells and tissues
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Role of sulfatide in normal and pathological cells and tissues

机译:硫化物在正常和病理细胞和组织中的作用

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Sulfatide is 3-O-sulfogalactosylceramide that is synthesized by two transferases (ceramide galactosyltransferase and cerebroside sulfotransferase) from ceramide and is specifically degraded by a sulfatase (arylsulfatase A). Sulfatide is a multifunctional molecule for various biological fields including the nervous system, insulin secretion, immune system, hemostasis/thrombosis, bacterial infection, and virus infection. Therefore, abnormal metabolism or expression change of sulfatide could cause various diseases. Here, we discuss the important biological roles of sulfatide in the nervous system, insulin secretion, immune system, hemostasis/thrombosis, cancer, and microbial infections including human immunodeficiency virus and infl uenza A virus. Our review will be helpful to achieve a comprehensive understanding of sulfatide, which serves as a fundamental target of prevention of and therapy for nervous disorders, diabetes mellitus, immunological diseases, cancer, and infectious diseases.
机译:硫化物是3-O-磺基半乳糖基神经酰胺,由神经酰胺的两种转移酶(神经酰胺半乳糖基转移酶和脑苷磺基转移酶)合成,并被硫酸酯酶(芳基硫酸酯酶A)特异性降解。硫化物是用于各种生物领域的多功能分子,包括神经系统,胰岛素分泌,免疫系统,止血/血栓形成,细菌感染和病毒感染。因此,硫酸酯的异常代谢或表达改变可能引起多种疾病。在这里,我们讨论了硫化物在神经系统,胰岛素分泌,免疫系统,止血/血栓形成,癌症以及包括人类免疫缺陷病毒和甲型流感病毒在内的微生物感染中的重要生物学作用。我们的综述将有助于获得对硫苷类的全面了解,后者是预防和治疗神经疾病,糖尿病,免疫性疾病,癌症和传染病的基本目标。

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