The synthesis of C-14-labeled N-succinimidyl-3-maleimidopropionate, a linker molecule for PEGylated biologics

摘要

Carbon-14 labeled linker molecule, N-succinimidyl-3-maleimidopropionate was prepared for disposition studies of PEGylated biologics. Our new route started with 100mCi of carbon-14 labeled Potassium cyanide (KCN) to prepare 55mCi of [1-C-14]N-succinimidyl-3-maleimidopropionate, 6 in five steps. This represents a multiple of 5.5x improvement in the yield of the desired labeled product compared with our previous synthesis.