Photonuclear production of ~(193m195m)pt and synthesis of radioactive cisplatin

摘要

Radiopharmaceuticals labelled with low-energy electron emitters will be used as radiotherapeutic agents in near future. Deceleration of emitted electrons leads to the energy release in an extremely small volume around the decay site and, as a result, the local dose is 104-107 Gy. In this case the radiotoxicity of Auger electrons is caused mainly (90%) by an indirect mechanisms.1'2 Practically all the antineoplastic Pharmaceuticals used in the oncology have a strong toxicity. The combined influence of bystander effect,3 a high density of deceleration losses, cytotoxic effect and apoptosis can be reached by application of radioactive cisplatin. It will allow considerable reduction of cisplatin dose and, consequently, reduction of the toxic cisplatin influence in the course of medical treatment.