Labelling of anilines, benzylamines and some N-heterocyclics using cycloocta-l,5-dienyliridium(I) -l,l,l,5,5,5-hexafluoro-pentan-2,4-dionate and isotopic hydrogen gas in DMF or DMA

摘要

A wide range of anilines, benzylamines and some N-heterocyclics can be ortho-deuterated at room temperature using deuterium gas and cycloocta-l,5-dienyliridiu-m(I)-l,l,l,5,5,5-hexafluoropentan-2,4-dionate in DMF or DMA. The method is applicable to labelling with tritium.