Expedient deuterolabelling of lignans using ionic liquid-DCL/D_2O under microwave heating

摘要

We have developed a fast and high-yielding deuteration method for lignans using 35% DCl/D_2O and ionic liquids, namely 1-butyl-3- methylimidazolium chloride [bmim]Cl or 1-butyl-3-methylimidazolium bromide [bmim]Br, as co-solvents, under MW irradiation. This methodology is generally applicable and simple to carry out with reaction times shortened from several days or 15 hours to 20-40 minutes. The ionic solvent is easily recycled.