COMPARATIVE TREATMENT OF ACNE VULGARISUSING PALOMAR LUX APPLIQUé TECHNIQUEAND DIRECT INTRALESIONAL INJECTION

摘要

Intralesional injection of triamcinolone (TMC) preparations is an effective therapy for cysticacne lesions. However, invasive delivery techniques limit the use of this modality to a relativelynarrow class of cases. Skin permeability can be enhanced through creating a lattice of micro-zones (islets) of light-induced limited thermal damage in the upper layers of epidermis. In thispaper, we directly compared safety and efficacy of delivering TMC acetonide with this noveltechnique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqué with a patternof absorbing centers has been used to create the lattice of islets of damage (LID). Quantitativeanalysis has included estimation of the following parameters: redness, diameter, and height ofacne lesions. Clinical photography has been used to document dynamics of lesion developmentat successive visits (two hours, 24 hours and one week post-treatment). Seven subjects haveparticipated in the study. No difference in lesion dynamics between the treatment and controlgroups was observed at two-hours follow-up. At 24-hours/one-week follow-ups, TMC-injectedand TMC-LID-delivered groups have demonstrated 82%/93% and 80%/89% improvement inheight of lesions in comparison to control (60%/68%). Delivery of TMC with the newly proposedLID technique is at least as effective as intralesional injection for treating inflammatory acnelesions. Enhancement of skin permeability using LID approach is a promising technique foraccelerating delivery of various compounds to their target areas in the skin.