Stereospecific ligands and their complexes. XXII. Synthesis and antitumor activity of palladium(II) complexes with some esters of (S,S)-ethylenediamine-N,N '-di-(2,2 '-di(4-hydroxy-benzyl))-acetic acid

摘要

Four new ligands and their palladium(II) complexes of general formula R-2-S,S-eddtyr (L1-L4) and [PdCl2(R-2-S,S-eddtyr)] (C1-C4) (R = ethyl, n-propyl, n-butyl and n-pentyl; S,S-eddtyr center dot 2HCl = ethylenediamine-N,N'-di-(2,2'-di(4-hydroxy-benzyl))-acetic acid dihydrochloride have been synthesized and characterized by microanalysis, infrared, H-1 and C-13 NMR spectroscopy. Cytotoxicity for ligands and complexes on two different cell lines (human breast cancer, MDA-MB-231 and human lung cancer, A549 cell lines) and human chronic lymphocytic leukemia cells (CLL) was investigated using MTT (3[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. (C) 2014 Elsevier Inc. All rights reserved.