Synthesis and characterization of new copper(I) complexes containing 4-(diphenylphosphane)benzoic acid and 'scorpionate' ligands with 'in vitro' superoxide scavenging activity

摘要

New copper(l) complexes have been synthesised from the reaction of CuCl with 4-(diphenylphosphane)benzoic acid and lithium tris(1H-pyrazol-1-yl)methanesulfonate, Li(SO3)C(pz)(3), sodium hydrotris(3-trifluoromethyl-1H-pyrazol-1-yl)borate, NaHB[3-(CF3)pz](3), potassium dihydrobis(1H-1,2,4-triazol-1-yl)borate, KH2B(tz)(2), hydrotris(1H-1,2,4-triazol-1-yl)borate, KHB(tz)(3), sodium hydrotris(1H-pyrazol-1-yl)borate, NaHB(pz)(3), potassium hydrotris(3,5-dimethyl-1H-pyrazol-1-yl)borate KHB(3,5-Me2pZ)(3) or potassium hydrotris(4-bromo-1H-pyrazol-1-yl)borate KHB(4-BrpZ)(3). The complexes obtained have been characterized by elemental analyses and FT-IR in the solid state, and by NMR (H-1 and P-31{H-1}) spectroscopy and conductivity measurements in solution. The solution data are consistent with partial dissociation of the sterically hindered complexes by way of breaking of Cu-P and Cu-N bonds. Electrospray mass spectrometry has been used to investigate the relative properties of the 4-(diphenylphosphane)benzoic acid and of the "scorpionate" ligands towards copper(I) ions. Chemiluminescence technique was used to evaluate the superoxide scavenging activity of these new copper complexes. (C) 2003 Elsevier Science Inc. All rights reserved. [References: 30]