Synthesis, Characterization and in vitro Cytotoxic Assay on Human PromyelocyticLeukemia Cells (HL60) of Organotin(IV) Complexes Derived of 4-(methylamino)benzoic Acid and 4-(Dimethylamino)benzoic Acid

摘要

Organotin(IV) carboxylate complexes derived from 4-(mefhylaraino)benzoic acid, 4-(NHCH3)C6H4COOH and 4-(dimethylamino)benzoic acid, 4-[N(CH3)2]C6H4COOH have been successfully synthesized. Two dibutyltin(IV) complexes with the general formulae [4-(R')C6H4COO]2Bu2Sn [R' = NHCH, 1; R' = N(CH3)2 3J and another two triphenyltin(IV) complexes with the general formulae 4-(R')C6H4COO(C6H5)3Sn [R' = NHCH3 2; R' = N(CH3)2 4] were successfully synthesized. The acids and complexes 1-4 obtained were characterized quantitatively and qualitatively. Results of the infrared and NMR spectroscopy on the acids and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. From the cytotoxic assay study, complex 2 revealed a significant result compared to complexes 1,3 and 4.