Dr. Frederick Mohs originally used bloodroot (Sanguinaria ca-nadensis) as the binder ("agglutinant") for zinc chloride in his topical fixative paste, first used in the 1930s in the method he termed chemosurgery.9 Bloodroot - containing the bioactive alkaloid sanguinarine - and zinc chloride are both powerful es-charotics, caustic agents that produce inflammation, necrosis, and eschar formation. Used indiscriminately they can produce substantial pain and scarring.
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