Synthesis and Biological Activities of 6-Hydroxyaurone Derivatives

摘要

A series of 6-hydroxyaurone derivatives were synthesized in satisfactory yields and characterized by IR, H-1 NMR, C-13 NMR, and HRMS or elemental analysis. The structure of compound 3e was further confirmed by X-ray crystal analysis. Bioassay results indicated that some of the target compounds displayed moderate herbicidal activity against the dicotyledonous plant Brassica campestris L. at 100 mu gmL(-1), and some compounds also showed significant antiproliferative activity against tumor cell lines Hela, HepG-2, and MCF-7.