Synthesis and antibacterial activity of 3-(substituted arylmethyl)-4- acylaminomethyloxazolidin-2-ones and derivatization to symmetrical twin-drug type molecules

摘要

In connection with our studies on antibacterial active compounds in the class of new oxazolidinones against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains, some molecular modifications were attempted. In this study, molecular modifications of 4-aminomethyloxazolidin-2- ones (3a) to the corresponding 4-acylaminomethyloxazolidin-2-one derivatives (3c-d) and preparations of the represented twin-drug type molecules (10-14) were investigated. Some additional 4-dialkylaminomethyloxazolidin-2-ones (2) were also synthesized. The synthesized compounds were evaluated for antibacterial activity with Gram-positive (S. aureus) and Gram-negative (E. coli) strains.