Synthesis of dispiro[oxindole-pyrrolidine]-thiazolo[3,2-a][1,3,5]triazines by 1,3-dipolar cycloaddition

摘要

Figure represented. The 1,3-dipolar cycloaddition of an azomethine ylide generated by a decarboxylative route from sarcosine and isatin to 7-arylmethylidene-3-aryl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-6(7H) -ones afforded novel dispiro[oxindole-pyrrolidine]-thiazolo[3,2-a][1,3,5] triazines in moderate yields. The structures of the products were determined and characterized thoroughly by NMR, MS, IR, and elemental analysis. The results of experiment indicated that this 1,3-dipolar cycloaddition proceeded with high stereoselectivity and regioselectivity.