Toward a novel approach to bis-β-lactam synthesis using Vilsmeier reagent as an efficient entity via Staudinger cycloaddition reaction

摘要

A facile synthesis of bis-β-lactams has been executed using chloromethylenedimethylammonium chloride (Vilsmeier reagent), prepared easily from N,N-dimethylformamide and phosphorus oxychloride. It works out as a versatile acid activator reagent for the direct [2 + 2] ketene-imine cycloaddition of substituted acetic acid and bis-imines in one-pot synthesis under mild conditions. Thus, this method has been proved as a high yielding, efficient, and cheap protocol for bis-β-lactam synthesis.