Synthesis and biological evaluation of new benzo[f]furo[2,3-h]and benzo[f]pyrano[2,3-h]coumarin derivatives.

摘要

Furocoumarins 3, 5 and pyranocoumarin 7 were synthesized from-the reaction of furonaphthalenediones 2, 4 and pyranonaphthalenedione 6 respectively with carbethoxymethylene(triphenyl)phosphorane in refluxing DCM for 3-6 hours or under microwave irradiation in toluene for a few minutes. Compounds 3, 5, 7 and their precursors were tested as anti-inflammatory/antioxidant agents. They were found to compete significantly high-DMSO for OH radicals, to scavenge O-2(-) and to inhibit lipoxygenase to a high extent.