A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides

摘要

In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected beta -lactam derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed. [References: 25]