Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl N-(3,4,4 ',5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) by using N-acyl iminium salts methodologies.

摘要

Some ways to use the N-acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N-(3,4,4',5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3-(3,4,5-trimethoxyphenyl)dihydropyrrolo[1,2-c]oxazole-1,5-dione). [References: 33]