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首页> 外文期刊>Journal of gynecologic surgery >Development of an Animal Model for Intrauterine Adhesions and Impact on Spontaneous Fertility
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Development of an Animal Model for Intrauterine Adhesions and Impact on Spontaneous Fertility

机译:宫腔粘连动物模型及其对自然繁殖的影响

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Background: Intrauterine adhesions (IUAs) or synechiae consist of partial or total (Asherman' s syndrome) apposition of the walls of the uterus and are the most common complications after operative hysteroscopy in patients of reproductive age. Occurrence rates can range from 4% to 45%. These adhesions cause several complications, including obstetrical complications. Objective: The aim of this research was to develop a model of intrauterine adhesions (IUA) in rabbits undergoing uterine curettage and study the impact on fertility. Materials and Methods: This study involved 40 uterine horns in 20 New Zealand white rabbits who were randomly divided into two groups. The 10 rabbits in Group 1 (? = 20 horns) underwent dual uterine-horn mechanical damage on days 1 and day 10, via abdominal insertion and abrasion of the mucosa with a 3-mm curette. The 10 rabbits in group 2 (n = 20 horns) served as controls who did not undergo curettage. All 20 rabbits were allowed to mate with male New Zealand rabbits 30 days after the surgical damage was performed, and, at 21 days, the female rabbits were subjected to ultrasound testing to confirm the pregnancies. Laparotomy and was also performed on all of the rabbits. The number of embryos was recorded for each group.
机译:背景:宫腔粘连(IUA)或粘膜粘膜由部分或全部子宫壁并置(阿舍曼氏综合征)组成,是育龄患者手术宫腔镜检查后最常见的并发症。发生率范围为4%至45%。这些粘连会引起多种并发症,包括产科并发症。目的:本研究的目的是建立子宫刮宫兔宫内粘连(IUA)模型并研究其对生育力的影响。材料和方法:本研究涉及20只新西兰大白兔的40个子宫角,将它们随机分为两组。第1组(?= 20角)中的10只兔子在第1天和第10天通过腹腔插入和3 mm刮匙刮擦粘膜遭受了双子宫角机械损伤。第2组中的10只兔子(n = 20角)用作未进行刮宫的对照。手术损伤发生30天后,所有20只兔子均与雄性新西兰兔子交配,在21天时,对雌性兔子进行超声检查以确认怀孕。剖腹手术也对所有兔子进行。记录每个组的胚胎数。

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